26.8

Important Functions of NP-LP Molecules

Many reports suggest that LPs produced from Bacillus spp. in nano-form are useful

for controlling mould, fungal and bacterial pathogens (Ongena and Jacques 2007;

Valodkar et al. 2011). Metal NPs have good antimicrobial activities, and NP-LP-

based antimicrobial formulations could be an effective fungicidal as well as bacteri-

cidal agents (Rai et al. 2009). Surfactin-functionalized poly methyl methacrylate

(PMMA) showed antimicrobial effect against Escherichia coli (300 μg/mL) of the

NP-LP molecules. Also, the low haemolytic activity exhibited by these NPs reduces

the amount of increased toxicity. A new surfactin-SMEDDS nano-formulation has

been developed, although more confirmation was needed for their anticancerous

activity (Hore 2019). The combination of surfactin along with nano-emulsion could

act as a great drug delivery agent and which could be successfully used as in

anticancer treatment (Table 26.2 and Fig. 26.2). Surfactin-based NPs also have

uses in overcoming multidrug resistance in cancerous cells, for example, surfactin-

loaded NPs loaded with doxorubicin. Doxorubicin has the purpose of stopping the

growth of the cancerous cells. It is type of chemotherapy used for the treatment

purpose of different type of cancer. β-Casein balanced out LP lyotropic liquid crystal

NPs has been utilized, i.e. these are the NPs of lipopeptides and the mixture of

doxorubicin which was an anthracycline, and therefore these lyotropic liquid NPs

Table 26.2 Describes some functions and applications of lipopeptides in different inorganic and

organic nano-formulations

Nano-formulation

Type of

nano-

formulation

Surfactin function

Application of

nano-formulation

References

Organic NPs

Polymeric

NPs

Enhance sorption

activities

Adsorbent and

antibacterial

Hore

(2019)

Surfactin-

functionalized poly

methyl methacrylate

(PMMA) NPs

Poly (methyl

methacrylate) (core)-

biosurfactant (shell)

NPs

Polymeric

NPs

Emulsifier,

pH-responsive gate

keeper, control

release of drugs

The

pH-responsive

and controlled

release nano-

carrier

Ohadi

et al.

(2020)

Inorganic NPs

Metal NPs

Stabilizer

Antimicrobial

Ahmad

et al.

(2019)

Anionic surfactin-

mediated silver NPs

Anionic surfactin-

mediated gold NPs

Metal NPs

Stabilizer

Anticancerous

Bali et al.

(2019)

Cadmium sulphide

NPs

Metal NPs

Stabilizer, capping

agent

Antimicrobial

Santos

et al.

(2019)

Surfactin-stabilized

biogenic silver nano-

cubes

Metal NPs

Stabilizer

Antipseudomonal

and antiendotoxin

Krishnan

et al.

(2017)

490

V. Chauhan et al.